Absorption and distribution of steviol glycosides in animal and human models


Considerable progress in the understanding of steviol glycoside metabolism has occurred recently. Stevioside and rebaudioside A are hydrolyzed to a common metabolite, the aglycone steviol by colonic and/or cecal bacteria, although, some will pass through the intestinal tract completely or partially intact. There is virtually no absorption of intact steviol glycosides in the gastrointestinal tract. Glucose moieties, released by the microbial metabolism of steviol glycosides, are presumably used for energy by colonic bacteria, as there is no evidence glucose is absorbed. Steviol is absorbed from the colon and elimin